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  Production and breeding of genetically modified animals

  KAC provides genetically engineered animals to meet your requests using genome editing tools.

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  Pharmacological studies

  KAC can perform various pharmacological studies using genetically engineered animals and animal models of human disease.

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  Preparation/evaluation of pathologic specimens

  KAC can prepare pathologic specimens for histopathological evaluation following pharmacological studies.

Pharmacological studies

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  Studies using pain models

  KAC prepares various pain models for evaluation.

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  Studies for allergies

  KAC performs various studies for allergies such as dermatitis model including atopic dermatitis, acute/chronic nasal allergy model, and pruritus evaluation.

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  Antitumor studies using cancer-bearing animal models

  KAC prepares cancer-bearing animal models by implanting mouse/rat/human cancer cells into the subcutaneous tissue, skin, organs, brain and veins for antitumor evaluation in mice/rats.

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  Studies using animal models of Rheumatoid /arthritis

  KAC performs studies in collagen arthritis model (chronic) or carrageenan-induced arthritis model (acute) with foot edema as an index.

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  Studies related to central nervous system/anti-stress

  KAC performs studies using animal models of cognitive dysfunction, anxiety and depression by instruments such as maze etc.. Anti-stress studies with gastric damage as an index are also possible.

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  Studies using animal models of Life style related disease

  KAC performs studies in life style related disease models such as hypertension, obesity, dyslipidemia and diabetes mellitus.

Studies in large animals

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  Studies in large animals

  KAC performs pharmacological/toxicological studies using pigs and dogs. In addition, KAC provides experimental pigs marketed by Zen-Noh. They can also be used in training of surgical procedures or tests for medical devices.

Contracted reseach related togenetically engineered mice

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  Production of genetically engineered animals

  KAC products KO/KI animals (mice/rats) using genome editing tools. KAC also establishes strains of animals produced by KAC.

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  Production/storage of frozen embryos/sperm

  KAC products frozen embryos/sperm of genetically engineered animals. KAC can also store frozen embryos/sperm owned by customer in the KAC facility.

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  Contracting for rasing/breeding of genetically engineered animals

  KAC keeps and breeds genetically engineered animals or animal modelof human disease (mice/rats) from customers. KAC can also provide animals bred by KAC.

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  Animal revival

  KAC performs individual restoration from frozen embryos/sperm of genetically engineered animals or animal modelof human disease. After individual restoration, the animals are provided for customers or kept/bred in KAC's Barrier System.

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  Cleaning of genetically engineered animals (production of SPF animals)

  KAC produces SPF animals by cleaning genetically engineered animals or or animal modelof human disease through in-vitro fertilization (IVF) or cesarean section.

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  Genotyping (PCR)

  KAC genotypes genetically engineered animals. KAC also accepts orders for operation of genotyping from animals (tail) or DNA extract sent by customers.

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  Microbiology monitoring

  KAC accepts orders for pathogenic microbial tests, general microbial tests, disinfection of facilities and environmental microbial analysis as microbial tests to maintain the environment.

Preparation/evaluation of pathological specimens

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  Preparation/evaluation of pathological specimens

  KAC prepares usual histopathological specimens as well as resin-embedded and ground specimen from samples containing hard tissues, such as bone or teeth, or implant materials such as titanium. In addition, KAC can prepare decalcified slice specimens.

Other studies

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  Toxicological studies/pharmacokinetic studies

  KAC performs not only PK and TK studies in various time schedules but also single dose toxicity studies (mouse/rat), repeated dose toxicity studies (rat), local irritation studies (rabbit) and sensitizing studies.

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  Studies related to regenerative medicine

  KAC performs teratoma formation studies, tumorigenicity studies, and implantation studies for iPS cells and stem cell-derived differentiated cells by applying technologies cultivated through antitumor studies. KAC also provides animals for implantation.

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  Rental of laboratories

  KAC rents the animal facilities for performing animal studies (mice, rats, rabbits, guinea pigs, dogs and pigs). KAC can provide flexible services such as experiment assistance by KAC staff, the provision of experimental instruments/supplies, and the use of devices brought in by the customers.

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  Preparation of antibodies

  KAC prepares monoclonal antibodies from antibody-producing cells. KAC accept orders for antibody purification from ascites or culture supernatant using a Protein A column, etc., on a small scale or large scale as requested.

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  in vitro Study (cell experiment)

  KAC performs cytotoxicity studies using various cancer cells and primary culture cells (WST-8, trypan blue and luminescence analysis, etc.)